Arhgef7 - Rho guanine nucleotide exchange factor (GEF7) Gene

Also Known as PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; beta-Pix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54126

Summary

Enables guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in lamellipodium assembly. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; positive regulation of GTPase activity; and positive regulation of growth hormone secretion. Located in several cellular components, including lamellipodium; postsynapse; and storage vacuole. Is expressed in several structures, including metanephros; nervous system; and retina. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef7 Products (9)

mRNA Protein Name
NM_001113517.2 NP_001106989.1 rho guanine nucleotide exchange factor 7 isoform a
NM_001113518.2 NP_001106990.1 rho guanine nucleotide exchange factor 7 isoform b
NM_001372321.1 NP_001359250.1 rho guanine nucleotide exchange factor 7 isoform d
NM_001372322.1 NP_001359251.1 rho guanine nucleotide exchange factor 7 isoform e
NM_001372323.1 NP_001359252.1 rho guanine nucleotide exchange factor 7 isoform f
NM_001372324.1 NP_001359253.1 rho guanine nucleotide exchange factor 7 isoform c
NM_001372325.1 NP_001359254.1 rho guanine nucleotide exchange factor 7 isoform g
NM_001372326.1 NP_001359255.1 rho guanine nucleotide exchange factor 7 isoform h
NM_017402.5 NP_059098.2 rho guanine nucleotide exchange factor 7 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
21828338 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10428811 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21048939 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
24029230 MGI
involved in lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
18325335 MGI
acts upstream of or within positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
21828338 MGI
acts upstream of or within positive regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
21828338 MGI
acts upstream of or within positive regulation of protein binding IMP
IMP: Inferred from mutant phenotype
21828338 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
21828338 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
18325335 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21828338 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
24297929 MGI
located in storage vacuole IDA
IDA: Inferred from direct assay
21828338 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 7

  • PAK-interacting exchange factor beta

  • Pak3 binding protein

Arhgef7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Arhgef7 Q9ES28 GIT2 Homo sapiens Q14161
Pull Down
21295525
Cross
Arhgef7 Q9ES28 PARVB Homo sapiens Q9HBI1
Pull Down
18325335
Intra
Arhgef7 Q9ES28 Git2 Mus musculus Q9JLQ2
Y2H
15102471
Intra
Arhgef7 Q9ES28 Parvb Mus musculus Q9ES46
Anti Tag CoIP
24035453
Cross
Arhgef7 Q9ES28 Shank2 Rattus norvegicus Q9QX74-4
Pull Down
20080968
Cross
Arhgef7 Q9ES28 Shank2 Rattus norvegicus Q9QX74-4
Anti Bait CoIP
20080968
Cross
Arhgef7 Q9ES28 Shank2 Rattus norvegicus Q9QX74-4
Crosslink
20080968
Cross
Arhgef7 Q9ES28 Git1 Rattus norvegicus Q9Z272
Pull Down
21295525
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00964 ARHGEF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21987 Arhgef7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgef7 NCBI NCBI:8874