2. Gene
  3. PARVB - parvin beta Gene

PARVB - parvin beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CGI-56

Gene ID: 29780 | Gene type: protein coding

About PARVB

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:43,999,211-44,172,939 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 14.3), heart (RPKM 12.4) and 24 other tissues.

Summary

This gene encodes a member of the parvin family of actin-binding proteins, which play a role in Cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

PARVB Products(4)

mRNA Protein Name
NM_001003828.3 NP_001003828.1 beta-parvin isoform a
NM_001243385.2 NP_001230314.1 beta-parvin isoform c
NM_001243386.2 NP_001230315.1 beta-parvin isoform d
NM_013327.5 NP_037459.2 beta-parvin isoform b

PARVB Protein Structure

CH

CH: Calponin homology (CH) domain (91 - 193)

CH

CH: Calponin homology (CH) domain (258 - 360)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

beta-parvin

affixin

Related Diseases

Diseases Alias
Coronary Restenosis
Mitochondrial Complex I Deficiency, Nuclear Type 33

MC1DN33

Nuclear Type Mitochondrial Complex I Deficiency 33

Mitochondrial Complex 1 Deficiency, Nuclear Type 33
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2b

Lgmd3

Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency

Limb-Girdle Muscular Dystrophy Type 3

Muscular Dystrophy, Limb-Girdle, Type 2b
Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10075 PARVB Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PARVB RGD RGD:1311485
Canis familiaris PARVB VGNC VGNC:108211
Felis catus PARVB VGNC VGNC:64046
Macaca mulatta PARVB VGNC VGNC:75606
Mus musculus PARVB MGD MGI:2153063
Bos taurus PARVB VGNC VGNC:32590