PARVB - parvin beta Gene

Also Known as CGI-56

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29780

About PARVB

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:43,999,211-44,172,939 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 14.3), heart (RPKM 12.4) and 24 other tissues.

Summary

This gene encodes a member of the parvin family of actin-binding proteins, which play a role in Cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

PARVB Products (4)

mRNA	Protein	Name
NM_001003828.3	NP_001003828.1	beta-parvin isoform a
NM_001243385.2	NP_001230314.1	beta-parvin isoform c
NM_001243386.2	NP_001230315.1	beta-parvin isoform d
NM_013327.5	NP_037459.2	beta-parvin isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18325335	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15005707	GOA
involved in cell projection assembly	IMP IMP: Inferred from mutant phenotype	15005707	GOA
involved in establishment or maintenance of cell polarity regulating cell shape	IMP IMP: Inferred from mutant phenotype	15005707	GOA
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	18325335	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	22869380	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	18325335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARVB Protein Structure

CH

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
beta-parvin	affixin

PARVB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	PARVB	Q9HBI1	Arhgef6	Mus musculus	Q8K4I3	IF	18325335
Cross	PARVB	Q9HBI1	Arhgef6	Mus musculus	Q8K4I3	Anti Bait CoIP	18325335
Cross	PARVB	Q9HBI1	Arhgef7	Mus musculus	Q9ES28	Anti Bait CoIP	18325335
Cross	PARVB	Q9HBI1	Arhgef7	Mus musculus	Q9ES28	Pull Down	18325335
Cross	PARVB	Q9HBI1	Arhgef7	Mus musculus	Q9ES28	IF	18325335

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coronary Restenosis
Mitochondrial Complex I Deficiency, Nuclear Type 33	MC1DN33 Nuclear Type Mitochondrial Complex I Deficiency 33 Mitochondrial Complex 1 Deficiency, Nuclear Type 33
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b	Lgmd2b Lgmd3 Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency Limb-Girdle Muscular Dystrophy Type 3 Muscular Dystrophy, Limb-Girdle, Type 2b
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10075	PARVB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PARVB	RGD	RGD:1311485
Canis familiaris	PARVB	VGNC	VGNC:108211
Felis catus	PARVB	VGNC	VGNC:64046
Macaca mulatta	PARVB	VGNC	VGNC:75606
Mus musculus	PARVB	MGD	MGI:2153063
Bos taurus	PARVB	VGNC	VGNC:32590
Others	PARVB	NCBI