Arhgef6 - Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 Gene

Also Known as alpha-PIX; 1600028C08Rik; 1700038J06Rik; 4930592P22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73341

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in lamellipodium assembly. Located in cell-cell junction and lamellipodium. Is expressed in somite and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 46. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef6 Products (11)

mRNA Protein Name
NM_001358573.2 NP_001345502.1 rho guanine nucleotide exchange factor 6 isoform 2
NM_001405168.1 NP_001392097.1 rho guanine nucleotide exchange factor 6 isoform 2
NM_001405169.1 NP_001392098.1 rho guanine nucleotide exchange factor 6 isoform 2
NM_001405170.1 NP_001392099.1 rho guanine nucleotide exchange factor 6 isoform 3
NM_001405171.1 NP_001392100.1 rho guanine nucleotide exchange factor 6 isoform 4
NM_001405172.1 NP_001392101.1 rho guanine nucleotide exchange factor 6 isoform 4
NM_001405173.1 NP_001392102.1 rho guanine nucleotide exchange factor 6 isoform 5
NM_001405174.1 NP_001392103.1 rho guanine nucleotide exchange factor 6 isoform 6
NM_001405175.1 NP_001392104.1 rho guanine nucleotide exchange factor 6 isoform 7
NM_001405176.1 NP_001392105.1 rho guanine nucleotide exchange factor 6 isoform 8
NM_152801.3 NP_690014.3 rho guanine nucleotide exchange factor 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18325335 MGI
Biological Process GO Annotation Evidence References Source
involved in lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
18325335 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
18325335 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 6

  • Rac/Cdc42 guanine exchange factor (GEF) 6

  • alpha PIX Rho GTPase guanine nucleotide exchange factor

  • rac/Cdc42 guanine nucleotide exchange factor 6

Arhgef6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Arhgef6 Q8K4I3 PARVB Homo sapiens Q9HBI1
Anti Bait CoIP
18325335
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00963 ARHGEF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21986 Arhgef6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28504 Arhgef6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgef6 NCBI NCBI:9459