Git2 - GIT ArfGAP 2 Gene

Also Known as CAT2; mKIAA0148; 1500036H07Rik; 5830420E16Rik; 6430510B20Rik; 9630056M03Rik; B230104M05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26431

Summary

Predicted to enable GTPase activator activity and metal ion binding activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral response to pain. Is active in calyx of Held. Is expressed in genitourinary system. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]

Git2 Products (4)

mRNA Protein Name
NM_001077359.1 NP_001070827.1 ARF GTPase-activating protein GIT2 isoform 2
NM_001077360.1 NP_001070828.1 ARF GTPase-activating protein GIT2 isoform 3
NM_001347400.1 NP_001334329.1 ARF GTPase-activating protein GIT2 isoform 4
NM_019834.3 NP_062808.3 ARF GTPase-activating protein GIT2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17310244 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
23870131 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26637799 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26637799 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
26637799 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
26637799 MGI
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
26637799 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
26637799 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
26637799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ARF GTPase-activating protein GIT2

  • ARF GAP GIT2

  • ARF GTPase activating protein 2

  • G protein-coupled receptor kinase-interactor 2

  • GRK-interacting protein 2

  • cool-interacting tyrosine-phosphorylated protein 2

Git2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Git2 Q9JLQ2 Arhgef7 Mus musculus Q9ES28
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05439 GIT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Git2 NCBI NCBI:9815