TREM1 - triggering receptor expressed on myeloid cells 1 Gene

Also Known as CD354; TREM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54210

About TREM1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,267,385-41,286,682 (from NCBI)

This gene has 7 transcripts (splice variants) and 85 orthologues. Biased expression in bone marrow (RPKM 10.0), appendix (RPKM 9.0) and 7 other tissues.

Summary

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by Bacterial and Fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

TREM1 Products (3)

mRNA	Protein	Name
NM_001242589.3	NP_001229518.1	triggering receptor expressed on myeloid cells 1 isoform 2 precursor
NM_001242590.3	NP_001229519.1	triggering receptor expressed on myeloid cells 1 isoform 3 precursor
NM_018643.5	NP_061113.1	triggering receptor expressed on myeloid cells 1 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables receptor decoy activity	IDA IDA: Inferred from direct assay	26561551	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	11602640	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	17098818	GOA

Cellular Component GO Annotation	Evidence	Références	Source
is active in cell surface	IDA IDA: Inferred from direct assay	17098818	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	26561551	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREM1 Protein Structure

V-set

0
100
200
234 a.a.

Protein Preferred Names	Protein Names
triggering receptor expressed on myeloid cells 1	triggering receptor expressed on monocytes 1

Recombinant TREM1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71380	TREM-1 Protein, Human (HEK293, His)	Q9NP99-1 (A21-R200)	≥ 95%, as determined by reducing SDS-PAGE.

TREM1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P811038	CD354 Antibody	WB, ICC/IF	Human, Mouse, Rat
HY-P84814	CD354 Antibody (YA4511)	WB, FC, ELISA	Human, Rat, Monkey
HY-P84814A	CD354 Antibody (YA4511)(PBS only)	WB, FC, ELISA	Human, Rat, Monkey

Related Diseases

Diseases	Alias
Maxillary Sinusitis
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Granulomatous Mastitis	Idiopathic Granulomatous Mastitis
Toxic Shock Syndrome	Septic Shock Toxic Shock Tss Shock, Septic Staphylococcal Toxic Shock Syndrome Tss - [Toxic Shock Syndrome]
Chorioamnionitis
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease
Pyelonephritis
Suppurative Cholangitis
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Amyotrophic Lateral Sclerosis 3	ALS3 Amyotrophic Lateral Sclerosis Type 3
Acute Cholangitis
Petrous Apex Meningioma	Meningioma Of The Petrous Ridge
Bacterial Sepsis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P3211A	Nangibotide TFA	Inhibitor	99.86%	Phase 2
HY-P3211	Nangibotide	Inhibitor	98.53%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P990650	PY159	Inhibitor	98.44%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-157122	VJDT	Inhibitor	99.68%	Unkown
HY-174369	TREM2 agonist-3		99.39%	Unkown
HY-P10086	TREM-1 inhibitory peptide GF9	Inhibitor	99.41%	Unkown
HY-P11077	LR-17	Inhibitor	97.52%	Unkown
HY-182702	As48		/	Unkown
HY-P10938	LP17 (human)	Inhibitor	90.14%	Unkown
HY-RS15002	TREM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16560	Trem1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10088	Mouse TREM-1 SCHOOL peptide, control	Control	/	Unkown
HY-RS22992	Trem1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TREM1	VGNC	VGNC:79088
Mus musculus	TREM1	MGD	MGI:1930005
Felis catus	TREM1	VGNC	VGNC:66518
Bos taurus	TREM1	VGNC	VGNC:36298
Canis familiaris	TREM1	VGNC	VGNC:47793
Rattus norvegicus	TREM1	RGD	RGD:1309467
Others	TREM1	NCBI