NEURL1B - neuralized E3 ubiquitin protein ligase 1B Gene

Also Known as neur2; NEURL3; RNF67B; hNeur2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54492

About NEURL1B

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,641,263-172,691,540 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 15.4), colon (RPKM 11.9) and 23 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in actin Cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

NEURL1B Products (3)

mRNA Protein Name
NM_001142651.3 NP_001136123.1 E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2
NM_001308177.2 NP_001295106.1 E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR1
NM_001308178.2 NP_001295107.1 E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
19723503 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEURL1B Protein Structure

Neuralized

Neuralized: Neuralized (40 - 106)

Neuralized

Neuralized: Neuralized (280 - 347)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (500 - 549)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 555 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase NEURL1B

  • E3 ubiquitin-protein ligase NEURL3

Related Diseases

Diseases Alias
Aortic Valve Disease 1

  • Aortic Valve Disease

  • Bicuspid Aortic Valve

  • Aortic Valve Disorder

  • AOVD1

  • Bav

  • Bicuspid Aortic Valve Disease

  • Familial Bicuspid Aortic Valve

  • Aortic Valve Calcification

  • Aovd

  • Aortic Valve, Bicuspid

  • Aortic Valve, Calcification Of

  • Aortic Stenosis, Calcific

  • Familial Bav

  • Calcific Aortic Stenosis

  • Calcification Of Aortic Valve

  • Abnormality Of The Aortic Valve

  • Aortic Valve Disease, Type 1

  • Aortic Valve Disease 2

  • Bicommissural Aortic Valve
Spondylocostal Dysostosis 1, Autosomal Recessive

  • Jarcho-Levin Syndrome

  • SCDO1

  • Vertebral Anomalies

  • Spondylothoracic Dysplasia

  • Costovertebral Dysplasia

  • Spondylothoracic Dysostosis

  • Spondylocostal Dysostosis 1

  • Autosomal Recessive Spondylocostal Dysostosis 1

  • Spondylocostal Dysostosis, Autosomal Recessive, 1

  • Doid:0112365

  • Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-182008 NEURL1B-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NEURL1B VGNC VGNC:49893
Mus musculus NEURL1B MGD MGI:3643092
Felis catus NEURL1B VGNC VGNC:63782
Rattus norvegicus NEURL1B RGD RGD:1564984
Macaca mulatta NEURL1B VGNC VGNC:75292
Bos taurus NEURL1B VGNC VGNC:32014
Others NEURL1B NCBI