PROX1 - prospero homeobox 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5629

About PROX1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:213,983,151-214,041,510 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 1 paralogue. Biased expression in liver (RPKM 20.2), adrenal (RPKM 5.1) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

PROX1 Products (2)

mRNA	Protein	Name
NM_001270616.2	NP_001257545.1	prospero homeobox protein 1
NM_002763.5	NP_002754.2	prospero homeobox protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	18815287	GOA
enables DNA binding domain binding	IPI IPI: Inferred from physical interaction	15205472	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15143342	GOA
enables LBD domain binding	IPI IPI: Inferred from physical interaction	15143342	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	15143342	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15205472	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19210544	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in brain development	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in embryonic retina morphogenesis in camera-type eye	IEP IEP: Inferred from expression pattern	12692551	GOA
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	15232737	GOA
involved in kidney development	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in lens development in camera-type eye	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in lens fiber cell morphogenesis	IEP IEP: Inferred from expression pattern	11850194	GOA
involved in liver development	IEP IEP: Inferred from expression pattern	11789987	GOA
involved in lung development	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in lymphangiogenesis	IDA IDA: Inferred from direct assay	12412020	GOA
involved in lymphatic endothelial cell differentiation	IDA IDA: Inferred from direct assay	12198161	GOA
involved in lymphatic endothelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	18815287	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15205472	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15143342	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16488887	GOA
involved in negative regulation of bile acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	16488887	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17062673	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15205472	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	19264593	GOA
involved in pancreas development	IEP IEP: Inferred from expression pattern	11789987	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12198161	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19210544	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	19210544	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19210544	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18815287	GOA
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	23723244	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	12198161	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11850194	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11850194	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROX1 Protein Structure

HPD

0
200
400
600
737 a.a.

Protein Preferred Names	Protein Names
prospero homeobox protein 1	homeobox prospero-like protein PROX1

PROX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PROX1	Q92786	HNF1A	Homo sapiens	P20823	Anti Tag CoIP	19264593
Intra	PROX1	Q92786	HNF1A	Homo sapiens	P20823	Pull Down	19264593
Intra	PROX1	Q92786	CTBP2	Homo sapiens	P56545	Y2H	21988832
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Pull Down	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Anti Bait CoIP	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Confocal	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Y2H	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Gal4 VP16 Complement	15205472

Cross: Cross-species interaction Intra: Intraspecies interaction

PROX1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82009	PROX1 Antibody (YA1754)	WB	Human
HY-P82009A	PROX1 Antibody (YA1754)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Generalized Lymphatic Anomaly	Doid:0081031
Hereditary Lymphedema I	Lymphedema Hereditary Lymphedema Type I Congenital Primary Lymphedema Lmph1 Milroy Disease Nonne-Milroy Lymphedema Pcl Lymphedema Hereditary Type 1
Lymphangioma	Lymphatic Malformation Lymphatic Malformations Benign Lymphangioma Congenital Lymphangioma Lymphangiomas
Angiokeratoma Of Fordyce	Fordyce Angiokeratoma Fordyce'S Spot Fordyce-Type Angiokeratoma Of Scrotum
Acquired Hemangioma
Malignant Ciliary Body Melanoma	Malignant Melanoma Of Ciliary Body Melanoma Of The Ciliary Body
Ciliary Body Cancer	Malignant Neoplasm Of Ciliary Body Malignant Tumor Of Ciliary Body Malignant Tumor Of The Ciliary Body Neoplasm Of Ciliary Body Tumor Of The Ciliary Body Primary Malignant Neoplasm Of Ciliary Body Malignant Neoplasm Of Eyeball Malignant Neoplasm Of Uveal Tract Primary Malignant Neoplasm Of Sclera Primary Malignant Neoplasm Of Uveal Tract
Hemangioma	Hemangiomas
Lymphangiosarcoma	Skin Lymphangiosarcoma Stewart Treves Syndrome Lymphangiosarcoma Of Stewart And Treves Malignant Lymphangioendothelioma Stewart-Treves Syndrome
Capillary Lymphangioma	Microcystic Lymphatic Malformation Capillary Lymphatic Malformation Microcystic Infiltrating Lymphatic Malformation Microcystic Lymphangioma Superficial Lymphangioma Cutaneous Lymphangioma Circumscriptum Superficial Lymphatic Malformation Cutaneous Lymphangioma Lymphangioma Of Skin Lymphangioma Circumscriptum
Hypotrichosis-Lymphedema-Telangiectasia Syndrome	HLTS Hypotrichosis Lymphedema Telangiectasia Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Spindle Cell Hemangioma	Sch Spindle Cell Hemangioendothelioma
Inflammatory Breast Carcinoma	Inflammatory Breast Cancer Inflammatory Carcinoma Of Breast Mastitis Carcinomatosa Breast Cancer, Inflammatory Inflammatory Breast Neoplasms Inflammatory Adenocarcinoma Of Breast
Gorham'S Disease	Gorham-Stout Syndrome Osteolysis, Essential Disappearing Bone Disease Essential Osteolysis Gorham Disease Massive Osteolysis Phantom Bone Disease Cystic Angiomatosis Of Bone Diffuse Gorham-Stout Disease Osteolysis Massive Vanishing Bone Disease Massive Osteolyses
Hereditary Lymphedema	Milroy Disease
Mucocele Of Salivary Gland	Ranula Salivary Cyst Salivary Gland Mucocele Mucous Retention Cyst Of Salivary Gland Retention Cyst Of Salivary Gland Sialocele Cyst Of Salivary Gland Or Duct Extravasation Cyst Of Salivary Gland
Cystic Lymphangioma	Cystic Hygroma Cavernous Lymphangioma Macrocystic Lymphatic Malformation Cavernous Lymphatic Malformation Macrocystic Lymphangioma Lymphangioma, Cystic
Lymphedema-Distichiasis Syndrome	Lymphedema With Distichiasis Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus LPHDST Distichiasis-Lymphedema Syndrome Lymphedema Distichiasis Syndrome Hereditary Lymphedema-Distichiasis Syndrome Lymphedema Distichiasis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Capillary Hemangioma	Infantile Hemangioma Strawberry Nevus Of Skin Cellular Hemangioma Of Infancy Congenital Vascular Hamartoma Congenital Vascular Naevus Juvenile Hemangioma Strawberry Haemangioma Strawberry Nevus Hemangioma Capillary Hemangioma, Capillary Hemangioma, Cavernous
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Hennekam Syndrome	Hennekam Lymphangiectasia Lymphedema Syndrome Hennekam Lymphangiectasia-Lymphedema Syndrome Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome Lymphangiectasies And Lymphedema Hennekam Type Generalized Lymphatic Dysplasia Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS11203	PROX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185120	ProX1-(SS)-DOTAGA_R		/	Unkown
HY-185120A	ProX1-(SS)-DOTAGA		/	Unkown
HY-RS19733	Prox1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20455	Nprl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26229	Prox1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P991202	Anti-TSHR Antibody (M22)		99.46%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PROX1	VGNC	VGNC:76427
Mus musculus	PROX1	MGD	MGI:97772
Canis familiaris	PROX1	VGNC	VGNC:45017
Felis catus	PROX1	VGNC	VGNC:69080
Bos taurus	PROX1	VGNC	VGNC:33369
Rattus norvegicus	PROX1	RGD	RGD:1306890
Others	PROX1	NCBI