Phip - pleckstrin homology domain interacting protein Gene

Also Known as Ndrp; Wdr11; 2810004D21Rik; 4632404O06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83946

Summary

Predicted to enable lysine-acetylated histone binding activity. Involved in several processes, including positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of mitotic nuclear division; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including Insulin Receptor signaling pathway; positive regulation of protein phosphorylation; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; female reproductive system; retina; and urinary system. Orthologous to human PHIP (pleckstrin homology domain interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Phip Products (1)

mRNA Protein Name
NM_001081216.1 NP_001074685.1 PH-interacting protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
11018022 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
17636024 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20816727 MGI
acts upstream of or within insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
11018022 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
17636024 MGI
acts upstream of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17636024 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17636024 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17636024 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20816727 MGI
involved in positive regulation of insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
17636024 MGI
involved in positive regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
17636024 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17636024 MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
17636024 MGI
acts upstream of or within positive regulation of type B pancreatic cell proliferation IGI
IGI: Inferred from genetic interaction
17636024 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
20816727 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
20816727 MGI
involved in regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
17636024 MGI
acts upstream of type B pancreatic cell proliferation IGI
IGI: Inferred from genetic interaction
17636024 MGI
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
17636024 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PH-interacting protein

  • IRS-1 PH domain-binding protein

  • WD repeat domain 11

  • WD repeat-containing protein 11

  • neuronal differentiation-related protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-118716 PhIP 99.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-118716S PhIP-d3 / Unkown
HY-N16528 (-)-Byakangelicin / Unkown
HY-RS10436 PHIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118716R PhIP (Standard) / Unkown
HY-RS21408 Phip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27927 Phip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phip NCBI NCBI:55023