ABCC11 - ATP binding cassette subfamily C member 11 Gene

Also Known as WW; EWWD; MRP8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85320

About ABCC11

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:48,164,819-48,247,539 (from NCBI)

This gene has 9 transcripts (splice variants), 450 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 1.2), prostate (RPKM 0.5) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated Steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

ABCC11 Products (5)

mRNA Protein Name
NM_001370496.1 NP_001357425.1 ATP-binding cassette sub-family C member 11 isoform c
NM_001370497.1 NP_001357426.1 ATP-binding cassette sub-family C member 11 isoform a
NM_032583.4 NP_115972.2 ATP-binding cassette sub-family C member 11 isoform a
NM_033151.4 NP_149163.2 ATP-binding cassette sub-family C member 11 isoform a
NM_145186.3 NP_660187.1 ATP-binding cassette sub-family C member 11 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables ABC-type bile acid transporter activity IDA
IDA: Inferred from direct assay
15537867 GOA
enables ABC-type glutathione S-conjugate transporter activity IDA
IDA: Inferred from direct assay
15537867 GOA
enables ABC-type xenobiotic transporter activity IDA
IDA: Inferred from direct assay
15537867 GOA
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
15537867 GOA
enables purine nucleotide transmembrane transporter activity IDA
IDA: Inferred from direct assay
12764137 GOA
Biological Process GO Annotation Evidence Références Source
involved in bile acid and bile salt transport IDA
IDA: Inferred from direct assay
15537867 GOA
involved in leukotriene transport IDA
IDA: Inferred from direct assay
15537867 GOA
involved in organic anion transport IDA
IDA: Inferred from direct assay
15537867 GOA
involved in purine nucleotide transport IDA
IDA: Inferred from direct assay
12764137 GOA
involved in xenobiotic transport IDA
IDA: Inferred from direct assay
15537867 GOA
Cellular Component GO Annotation Evidence Références Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16359813 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16359813 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCC11 Protein Structure

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (170 - 428)

ABC_tran

ABC_tran: ABC transporter (527 - 661)

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (807 - 1086)

ABC_tran

ABC_tran: ABC transporter (1158 - 1306)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1382 a.a.
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 11

  • ATP-binding cassette protein C11

Related Diseases

Diseases Alias
Apocrine Gland Secretion, Variation In

  • Ear Wax, Wet/Dry

  • Axillary Odor, Variation In

  • Ewwd

  • Wet Wax

  • Ww

  • Cerumen, Variation In

  • Colostrum Secretion, Variation In

  • Earwax, Wet/Dry

  • Secretion, Gland, Apocrine, Variation In
Lateral Sinus Thrombosis

  • Thrombosis Of Lateral Venous Sinus

  • Thrombosis Transverse Sinus
Episodic Kinesigenic Dyskinesia 1

  • Paroxysmal Kinesigenic Choreoathetosis

  • Paroxysmal Kinesigenic Dyskinesia

  • Dystonia 10

  • Familial Paroxysmal Kinesigenic Dyskinesia

  • Episodic Kinesigenic Dyskinesia

  • EKD1

  • Pkc

  • Pkd

  • Dyt10

  • Familial Pkd

  • Paroxysmal Kinesigenic Choreathetosis

  • Familial Paroxysmal Dystonia

  • Dystonia, Familial Paroxysmal

  • Dyt-Prrt2

  • Dystonia, Type 10
Dubin-Johnson Syndrome

  • DJS

  • Chronic Idiopathic Jaundice

  • Jaundice, Chronic Idiopathic

  • Hyperbilirubinemia, Dubin-Johnson Type

  • Hyperbilirubinemia Ii

  • Hyperbilirubinemia Type 2

  • Conjugated Hyperbilirubinemia

  • Dubin-Sprinz Disease

  • Sprinz-Nelson Syndrome

  • Hblrdj

  • Dubin Johnson Syndrome

  • Hyperbilirubinemia 2

  • Black Liver-Jaundice Syndrome

  • Chronic Idiopathic Jaundice With Pigmented Liver

  • Dubin-Sprinz Syndrome

  • Hyperbilirubinaemia Type 2

  • Djs - [Dubin-Johnson Syndrome]
Intracranial Sinus Thrombosis

  • Sinus Thrombosis, Intracranial
Otomycosis

  • Singapore Ear
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00059 ABCC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown