ISX - intestine specific homeobox Gene
Also Known as Pix-1; RAXLX
Species: Homo sapiens
About ISX
This gene has 2 transcripts (splice variants), 106 orthologues, 50 paralogues and is associated with 51 phenotypes. Biased expression in duodenum (RPKM 20.1), colon (RPKM 15.2) and 1 other tissue.
Summary
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 Amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]
ISX Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001303508.2 | NP_001290437.1 | intestine-specific homeobox |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables sequence-specific double-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
28473536 | GOA |
ISX Protein Structure
Homeobox: Homeobox domain (83 - 139)
- 0
- 100
- 200
- 245 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
intestine-specific homeobox |
|
ISX Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
ISX | Q2M1V0 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | GSC2 | Homo sapiens | O15499 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | GSC2 | Homo sapiens | O15499 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | ROR2 | Homo sapiens | Q01974 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | ROR2 | Homo sapiens | Q01974 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
ISX | Q2M1V0 | DAZAP2 | Homo sapiens | Q15038 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hypervitaminosis A |
|
|
| Macular Degeneration, Age-Related, 10 |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | ISX | VGNC | VGNC:42115 |
| Mus musculus | ISX | MGD | MGI:1918847 |
| Macaca mulatta | ISX | VGNC | VGNC:107796 |
| Bos taurus | ISX | VGNC | VGNC:30305 |
| Felis catus | ISX | VGNC | VGNC:62981 |
| Rattus norvegicus | ISX | RGD | RGD:1592776 |
| Others | ISX | NCBI |