ISX - intestine specific homeobox Gene

Also Known as Pix-1; RAXLX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91464

About ISX

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,066,158-35,087,387 (from NCBI)

This gene has 2 transcripts (splice variants), 106 orthologues, 50 paralogues and is associated with 51 phenotypes. Biased expression in duodenum (RPKM 20.1), colon (RPKM 15.2) and 1 other tissue.

Summary

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 Amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]

ISX Products (1)

mRNA Protein Name
NM_001303508.2 NP_001290437.1 intestine-specific homeobox
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISX Protein Structure

Homeobox

Homeobox: Homeobox domain (83 - 139)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

intestine-specific homeobox

  • RAX-like homeobox

ISX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ISX Q2M1V0 POU6F2 Homo sapiens P78424 32296183
Intra
ISX Q2M1V0 POU6F2 Homo sapiens P78424 32296183
Intra
ISX Q2M1V0 GSC2 Homo sapiens O15499 32296183
Intra
ISX Q2M1V0 GSC2 Homo sapiens O15499 32296183
Intra
ISX Q2M1V0 UBAP2 Homo sapiens Q5T6F2 32296183
Intra
ISX Q2M1V0 UBAP2 Homo sapiens Q5T6F2 32296183
Intra
ISX Q2M1V0 UBAP2 Homo sapiens Q5T6F2 32296183
Intra
ISX Q2M1V0 ROR2 Homo sapiens Q01974 32296183
Intra
ISX Q2M1V0 ROR2 Homo sapiens Q01974 32296183
Intra
ISX Q2M1V0 DAZAP2 Homo sapiens Q15038 32296183
Intra
ISX Q2M1V0 DAZAP2 Homo sapiens Q15038 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypervitaminosis A
  • Hypervitaminosis A, Susceptibility To

  • Hyperalimentation Of Vitamin A

Macular Degeneration, Age-Related, 10
  • ARMD10

  • Age Related Macular Degeneration 10

  • Macular Degeneration, Age-Related, Type 10

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris ISX VGNC VGNC:42115
Mus musculus ISX MGD MGI:1918847
Macaca mulatta ISX VGNC VGNC:107796
Bos taurus ISX VGNC VGNC:30305
Felis catus ISX VGNC VGNC:62981
Rattus norvegicus ISX RGD RGD:1592776
Others ISX NCBI