LC3B recruiter 2
Based on 1 Customer Validation
LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 (HY-10008) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both). Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity.
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- Pureté: 98.11%
- CAS No.: 380636-64-6
- Formule: C10H9ClN2O2
- Masse moléculaire:224.64
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 380636-64-6
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Appearance Solid
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Masse moléculaire 224.64
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Formule C10H9ClN2O2
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Color White to off-white
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SMILES
CCN1C(NC2=CC(Cl)=CC=C2C1=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 35 mg/mL (155.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4516 mL | 22.2578 mL | 44.5157 mL | 111.2892 mL |
| 5 mM | 0.8903 mL | 4.4516 mL | 8.9031 mL | 22.2578 mL | |
| 10 mM | 0.4452 mL | 2.2258 mL | 4.4516 mL | 11.1289 mL | |
| 15 mM | 0.2968 mL | 1.4839 mL | 2.9677 mL | 7.4193 mL | |
| 20 mM | 0.2226 mL | 1.1129 mL | 2.2258 mL | 5.5645 mL | |
| 25 mM | 0.1781 mL | 0.8903 mL | 1.7806 mL | 4.4516 mL | |
| 30 mM | 0.1484 mL | 0.7419 mL | 1.4839 mL | 3.7096 mL | |
| 40 mM | 0.1113 mL | 0.5564 mL | 1.1129 mL | 2.7822 mL | |
| 50 mM | 0.0890 mL | 0.4452 mL | 0.8903 mL | 2.2258 mL | |
| 60 mM | 0.0742 mL | 0.3710 mL | 0.7419 mL | 1.8548 mL | |
| 80 mM | 0.0556 mL | 0.2782 mL | 0.5564 mL | 1.3911 mL | |
| 100 mM | 0.0445 mL | 0.2226 mL | 0.4452 mL | 1.1129 mL |
LC3B recruiter 2 Related Classifications
HY-168892 Related Classifications
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