Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp

  • Experientia. 1994 Sep 15;50(9):843-5. doi: 10.1007/BF01956468.
P A Horton  1 ,  R E Longley ,  O J McConnell ,  L M Ballas
Affiliations
  • 1. Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946.
PMID: 7925852 DOI: 10.1007/BF01956468
Abstract

Staurosporine aglycone (K252-c) (compound 1) and arcyriaflavin A (2) were isolated from a specimen of the marine ascidian, Eudistoma sp., collected off the coast of West Africa. In addition to expressing micromolar and submicromolar inhibition of enzyme activity against seven protein kinase C isoenzymes and inhibition of proliferation of the human lung Cancer A549 and P388 murine leukemia cell lines, 1 also inhibited cell adhesion of the EL-4.IL-2 cell line and expressed activity in the K562 bleb and neutrophil assays.

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