WAY-123223
WAY-123223 is an orally active potassium channel (Potassium Channel) blocker. WAY-123223 prolongs the transmembrane action potential duration and cardiac refractory period of canine Purkinje fibers. In canine models, WAY-123223 increases the ventricular fibrillation threshold, restores sinus rhythm from ventricular fibrillation, and exerts antiarrhythmic effects. WAY-123223 can be used in research related to cardiovascular diseases such as arrhythmias.
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- CAS No.: 137941-92-5
- Formule: C21H25N3O4S
- Masse moléculaire:415.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
WAY-123223 (Compound 12) (0.3-3 μM) dose-dependently prolongs the action potential duration of canine Purkinje fibers; at a concentration of 3 μM (BCL = 300 ms), it increases APD-60mV by 27%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dog (pentobarbital-anesthetized, open-chest)[1]
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Dosage:5 mg/kg); 10.0 mg/kg (intraduodenal)
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Administration:i.v.; single dose; intraduodenal; single dose
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Result:Increased the ventricular fibrillation threshold from a predrug value of 8.2 mA to 25 mA (a 3-fold increase relative to control).
Restored sinus rhythm spontaneously from ventricular fibrillation without electrical countershock in some cases.
Increased AERP by 45%, increased VERP by 21%, decreased ACT by 9%, decreased VCT by 2%, decreased HR by 18%, and decreased MBP by 9% at 5.0 mg/kg i.v.
(all values are percent change from predrug state).
Increased AERP by 31%, increased VERP by 20%, decreased ACT by 4%, increased VCT by 1%, decreased HR by 15%, and decreased MBP by 5% at 10.0 mg/kg intraduodenal (all values are percent change from predrug state).
Chemical Information
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CAS No. 137941-92-5
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Masse moléculaire 415.51
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Formule C21H25N3O4S
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SMILES
CS(=O)(NC1=CC=C(OC[C@@H](O)CN(C)CC2=NC3=CC=CC=C3C=C2)C=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WAY-123223 Related Classifications
HY-119747 Related Classifications
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