1006718-20-2
Chemical Structure
Terazosin-d8
- CAS No.: 1006718-20-2
- Formula:C19H17D8N5O4
- Molecular Weight:395.48
IUPAC Name: (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)(tetrahydrofuran-2-yl)methanone
InChIKey: VCKUSRYTPJJLNI-YEBVBAJPSA-N
SMILES: NC1=NC(N2C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C2([2H])[2H])C(C3CCCO3)=O)=NC4=C1C=C(OC)C(OC)=C4
Biological Activity: Terazosin-d8 is deuterium labeled Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].
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Terazosin-d8 | Terazosin-d8 is deuterium labeled Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment. | |||||||||||||||||||||
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Terazosin | 99.28% | Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment. | ||||||||||||||||||||
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Similarity Score 1.00
HY-B0371B(R)-Terazosin -
Similarity Score 1.00
HY-B0371D(S)-Terazosin -
Similarity Score 0.99
HY-B0371FRTerazosin hydrochloride (Standard) -
Similarity Score 0.97
HY-B0371ATerazosin hydrochloride dihydrate -
Similarity Score 0.77
HY-123563Metazosin -
Similarity Score 0.76
HY-106416Neldazosin -
Similarity Score 0.75
HY-185003α1A-AR ligand-1 -
Similarity Score 0.74
HY-128613Terazosin-md -
Similarity Score 0.74
HY-107326ABunazosin hydrochloride -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Michel MC, et al. Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate. J Auton Pharmacol. 1996 Feb;16(1):21-8. [Content Brief]
- [3]. Vincent J, et al. Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans. J Clin Invest. 1992 Nov;90(5):1763-8. [Content Brief]
