1043446-39-4
Chemical Structure
CH5137291
- CAS No.: 1043446-39-4
- Formula:C18H14F3N5O3S2
- Molecular Weight:469.46
IUPAC Name: 6-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)pyridine-2-sulfonamide
InChIKey: JIIHFLNYGVNTFP-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(N2C(C(C)(C)N(C2=S)C3=CC=CC(S(=O)(N)=O)=N3)=O)C=C1C(F)(F)F
Biological Activity: CH5137291 is an orally active pure antagonist of the androgen receptor (AR), without generating agonist metabolites. CCH5137291 directly blocks the transfer of AR from the cytoplasm to the nucleus. H5137291 can completely inhibit tumor growth in cells and mouse models of castration-resistant prostate cancer models. CH5137291 can be used for the study of castration-resistant prostate cancer (CRPC)[1][2].
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CH5137291 | CH5137291 is an orally active pure antagonist of the androgen receptor (AR), without generating agonist metabolites. CCH5137291 directly blocks the transfer of AR from the cytoplasm to the nucleus. H5137291 can completely inhibit tumor growth in cells and mouse models of castration-resistant prostate cancer models. CH5137291 can be used for the study of castration-resistant prostate cancer (CRPC). | |||||||||||||||||||||
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- [1]. Yoshino H, et al. Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer. Bioorg Med Chem. 2010 Dec 1;18(23):8150-7. [Content Brief]
- [2]. CH5137291 can be used for the study of castration-resistant prostate cancer (CRPC) [1][2]. [Content Brief]
Keywords
