117704-65-1
Chemical Structure
Pradimicin A
- CAS No.: 117704-65-1
- Formula:C40H44N2O18
- Molecular Weight:840.78
IUPAC Name: ((5S,6S)-1,6,9,14-tetrahydroxy-5-(((2S,3R,4S,5S,6R)-3-hydroxy-6-methyl-5-(methylamino)-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-11-methoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carbonyl)-D-alanine
InChIKey: WPICPWIIIBCXCV-NJGWPHBESA-N
SMILES: OC1=C2C3=C(O)C(C(N[C@H](C)C(O)=O)=O)=C(C)C=C3[C@@H]([C@H](C2=CC4=C1C(C5=CC(OC)=CC(O)=C5C4=O)=O)O)O[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)NC)O[C@H]7[C@@H]([C@H]([C@@H](CO7)O)O)O)O
Biological Activity: Pradimicin A is a potent antifungal agent with a minimum inhibitory concentration (MIC) of 4 μg/mL against Candida rugosa. Pradimicin A exhibits antiviral activity against SARS-CoV, human immunodeficiency virus (HIV) and other enveloped viruses. Pradimicin A exerts its fungicidal activity through a Ca2+-dependent mechanism, which induces fungal lysis. Pradimicin A can be used in research related to fungal infections, HIV infections and COVID-19[1][2][3][4][5].
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Pradimicin A | Pradimicin A is a potent antifungal agent with a minimum inhibitory concentration (MIC) of 4 μg/mL against Candida rugosa. Pradimicin A exhibits antiviral activity against SARS-CoV, human immunodeficiency virus (HIV) and other enveloped viruses. Pradimicin A exerts its fungicidal activity through a Ca2+-dependent mechanism, which induces fungal lysis. Pradimicin A can be used in research related to fungal infections, HIV infections and COVID-19. | |||||||||||||||||||||
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References
- [1]. Nakagawa Y, et al. Molecular basis of N-glycan recognition by pradimicin a and its potential as a SARS-CoV-2 entry inhibitor. Bioorg Med Chem. 2024 May 1;105:117732. [Content Brief]
- [2]. Nakagawa Y, et al. Mapping of the primary mannose binding site of pradimicin A. J Am Chem Soc. 2011;133(43):17485-17493. [Content Brief]
- [3]. Miyanishi W, et al. d-Mannose binding, aggregation property, and antifungal activity of amide derivatives of pradimicin A. Bioorg Med Chem. 2022;55:116590. [Content Brief]
- [4]. Nakagawa Y, et al. Molecular Basis of Mannose Recognition by Pradimicins and their Application to Microbial Cell Surface Imaging. Cell Chem Biol. 2019;26(7):950-959.e8. [Content Brief]
- [5]. Guo Y, et al. Isolation, biosynthesis, and biological activity of pradimicins from actinomycetes. Bioorg Chem. 2025;164:108884. [Content Brief]
