1246820-19-8
1246820-19-8
Chemical Structure
Loxapine-d8 hydrochloride
- CAS No.: 1246820-19-8
- Formula:C18H11D8Cl2N3O
- Molecular Weight:335.86
IUPAC Name: 2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine hydrochloride
InChIKey: JSXBVMKACNEMKY-KTSBLNPMSA-N
SMILES: ClC=1C=C2C(=NC=3C(OC2=CC1)=CC=CC3)N4C(C(N(C)C(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H].Cl
Biological Activity: Loxapine-d8 hydrochloride is the deuterium labeled Loxapine. Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][2].
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Loxapine-d8 hydrochloride | Loxapine-d8 hydrochloride is the deuterium labeled Loxapine. Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. | |||||||||||||||||||||
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Loxapine-d8 | 99.13% | Loxapine-d8 is the deuterium labeled Loxapine. | ||||||||||||||||||||
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Loxapine hydrochloride | Loxapine hydrochloride is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. [Content Brief]
