1346599-75-4
Chemical Structure
DM-4107
- CAS No.: 1346599-75-4
- Formula:C26H25ClN2O5
- Molecular Weight:480.94
IUPAC Name: 4-(5-chloro-2-(2-methyl-4-(2-methylbenzamido)benzamido)phenyl)-4-hydroxybutanoic acid
InChIKey: AJMZAIPORREFDJ-UHFFFAOYSA-N
SMILES: CC1=CC=CC=C1C(NC2=CC(C)=C(C(NC3=C(C(O)CCC(O)=O)C=C(Cl)C=C3)=O)C=C2)=O
Biological Activity: DM-4107 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4107 inhibits the ability of human liver transporters NTCP, BSEP, MRP3, MRP4 (IC50 values are 95.6, 119, 61.2, 37.9 μM, respectively) and bile acid transport in SCHH cells. DM-4107 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD)[1][2].
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DM-4107 | DM-4107 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4107 inhibits the ability of human liver transporters NTCP, BSEP, MRP3, MRP4 (IC50 values are 95.6, 119, 61.2, 37.9 μM, respectively) and bile acid transport in SCHH cells. DM-4107 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD). | |||||||||||||||||||||
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References
- [1]. Wan W L, et al. Synthesis of the major metabolites of Tolvaptan[J]. Chinese Chemical Letters, 2012, 23(12): 1343-1346.
- [2]. Slizgi JR, et al. Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury? Toxicol Sci. 2016 Jan;149(1):237-50. [Content Brief]
