141-05-9
Chemical Structure
Diethyl maleate
Synonym(s): Maleic acid diethyl ester
- CAS No.: 141-05-9
- Formula:C8H12O4
- Molecular Weight:172.18
IUPAC Name: diethyl maleate
InChIKey: IEPRKVQEAMIZSS-WAYWQWQTSA-N
SMILES: O=C(OCC)/C=C\C(OCC)=O
Biological Activity: Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO-. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Diethyl maleate | 98.05% | Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO-. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases. | ||||||||||||||||||||
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Similarity Score 1.00
HY-W010056RDiethyl fumarate (Standard) -
Similarity Score 0.83
HY-W703021Diethyl chloromaleate -
Similarity Score 0.83
HY-W019696Monoethyl fumarate -
Similarity Score 0.81
HY-Y0836Diethyl succinate -
Similarity Score 0.81
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Similarity Score 0.80
HY-17363Dimethyl fumarate -
Similarity Score 0.79
HY-W017567Ethyl (E)-2-hexenoate -
Similarity Score 0.79
HY-W143131SDiethyl itaconate,98% (stabilized with TBC)-13C5 -
Similarity Score 0.79
HY-79076RDiethyl pentanedioate (Standard) -
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