1477-19-6
Chemical Structure
Benzarone
- CAS No.: 1477-19-6
- Formula:C17H14O3
- Molecular Weight:266.29
IUPAC Name: (2-ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone
InChIKey: RFRXIWQYSOIBDI-UHFFFAOYSA-N
SMILES: CCC1=C(C(C2=CC=C(O)C=C2)=O)C3=CC=CC=C3O1
Biological Activity: Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also acts as an uncoupler of oxidative phosphorylation. Benzarone can cause liver damage and promote cell apoptosis and necrosis. Benzarone can be used to lower serum uric acid levels and for research in vascular diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Benzarone | 98.79% | Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also acts as an uncoupler of oxidative phosphorylation. Benzarone can cause liver damage and promote cell apoptosis and necrosis. Benzarone can be used to lower serum uric acid levels and for research in vascular diseases. | ||||||||||||||||||||
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Benzarone (Standard) | ≥98% | Benzarone (Standard) is the analytical standard of Benzarone. This product is intended for research and analytical applications. Benzarone is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC50 of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels. | ||||||||||||||||||||
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- [1]. Wempe MF, et, al. Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem. 2011 Apr 28;54(8):2701-13. [Content Brief]
- [2]. Priska Kaufmann, et al. Mechanisms of benzarone and benzbromarone-induced hepatic toxicity. Hepatology. 2005 Apr;41(4):925-35. [Content Brief]
- [3]. S G Wood, et al. Metabolic fate of the thrombolytic agent benzarone in man: comparison with the rat and dog. [Content Brief]
Keywords
