169317-77-5
Chemical Structure
Sabarubicin hydrochloride
Synonym(s): MEN 10755 hydrochloride
- CAS. Nr.: 169317-77-5
- Formula:C32H38ClNO13
- Molecular Weight:680.10
IUPAC Name: (7S,9S)-7-(((2R,4S,5S,6S)-5-(((2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
InChIKey: BSRQHWFOFMAZRL-BODGVHBXSA-N
SMILES: OC1=C2C(C(C3=CC=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)O)N)O)=C1C[C@](O)(C4)C(CO)=O.Cl
Biological Activity: Sabarubicin hydrochloride (MEN 10755 hydrochloride) is a disaccharide analog of Doxorubicin (HY-15142A). Sabarubicin hydrochloride stimulates topoisomerase II-mediated DNA cleavage, induces DNA strand breaks and Apoptosis. Sabarubicin hydrochloride binds to and stabilizes telomeric G-quadruplex DNA. Sabarubicin hydrochloride is applicable to research related to ovarian tumors, breast cancer and lung cancer[1][2][3][4].
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Sabarubicin hydrochloride | Sabarubicin hydrochloride (MEN 10755 hydrochloride) is a disaccharide analog of Doxorubicin (HY-15142A). Sabarubicin hydrochloride stimulates topoisomerase II-mediated DNA cleavage, induces DNA strand breaks and Apoptosis. Sabarubicin hydrochloride binds to and stabilizes telomeric G-quadruplex DNA. Sabarubicin hydrochloride is applicable to research related to ovarian tumors, breast cancer and lung cancer. | |||||||||||||||||||||
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- [1]. Arcamone F, et al. Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo. Journal of the National Cancer Institute. 1997 Aug 20;89(16):1217-23. [Content Brief]
- [2]. Bigioni M, et al. Antitumour effect of combination treatment with Sabarubicin (MEN 10755) and cis-platin (DDP) in human lung tumour xenograft. Cancer chemotherapy and pharmacology. 2008 Sep;62(4):621-9. [Content Brief]
- [3]. Mazzini S, et al. Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755. Bioorganic & medicinal chemistry. 2010 Feb 15;18(4):1497-506. [Content Brief]
- [4]. Manet I, et al. Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures. Physical chemistry chemical physics : PCCP. 2011 Jan 14;13(2):540-51. [Content Brief]
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