1884220-36-3
1884220-36-3
Chemical Structure
SBI-0206965
- CAS No.: 1884220-36-3
- Formula:C21H21BrN4O5
- Molecular Weight:489.32
IUPAC Name: 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
InChIKey: NEXGBSJERNQRSV-UHFFFAOYSA-N
SMILES: CNC(C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br)=O
Biological Activity: SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation[1][2][3].
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SBI-0206965 | 99.92% | SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation. | ||||||||||||||||||||
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SBI-0206965 (Standard) | ≥98% | SBI-0206965 (Standard) is the analytical standard of SBI-0206965 (HY-16966). This product is intended for research and analytical applications. SBI-0206965 is a potent, selective and cell permeable autophagy Kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 Kinase and 711 nM for the highly related Kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation. | ||||||||||||||||||||
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References
- [1]. Lu J, et al. Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell RenalCarcinoma and the Antitumor Effects of SBI-0206965. EBioMedicine. 2018 Aug;34:85-93. [Content Brief]
- [2]. Egan DF, et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16;59(2):285-97. [Content Brief]
- [3]. Hawley SA, et al. BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation. Int J Mol Sci. 2023 Dec 29;25(1):453. [Content Brief]
