197801-88-0
197801-88-0
Chemical Structure
SN003
- CAS. Nr.: 197801-88-0
- Formula:C19H25N5O2
- Molecular Weight:355.43
IUPAC Name: N-(4-methoxy-2-methylphenyl)-1-(1-methoxybutan-2-yl)-6-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-4-amine
InChIKey: FZMBHAQCHCEGNN-UHFFFAOYSA-N
SMILES: CC1=CC(N(C(COC)CC)N=N2)=C2C(NC3=CC=C(OC)C=C3C)=N1
Biological Activity: SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat[1][2][3].
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SN003 | SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat. | |||||||||||||||||||||
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References
- [1]. J S Dileep Kumar, et al. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg Med Chem. 2006 Jun 15;14(12):4029-34. [Content Brief]
- [2]. Andrzej Wróbel, et al. Inhibition of the CRF1 receptor influences the activity of antidepressant drugs in the forced swim test in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):769-774. [Content Brief]
- [3]. Simeon J Ramsey, et al. Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo. Br J Pharmacol. 2011 Oct;164(3):992-1007. [Content Brief]
