198419-91-9
198419-91-9
Chemical Structure
LY367385
- CAS No.: 198419-91-9
- Formula:C10H11NO4
- Molecular Weight:209.20
IUPAC Name: (S)-4-(amino(carboxy)methyl)-3-methylbenzoic acid
InChIKey: SGIKDIUCJAUSRD-QMMMGPOBSA-N
SMILES: OC([C@H](C1=C(C=C(C(O)=O)C=C1)C)N)=O
Biological Activity: LY367385 is a highly selective and potent mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY367385 | 99.0% | LY367385 is a highly selective and potent mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects. | ||||||||||||||||||||
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References
- [1]. Clark et al. (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780.
- [2]. Bruno V, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 1999 Feb;38(2):199-207. [Content Brief]
