204268-63-3
204268-63-3
Chemical Structure
NCX-530
- CAS No.: 204268-63-3
- Formula:C26H21ClN2O7
- Molecular Weight:508.91
IUPAC Name: 3-((nitrooxy)methyl)phenyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
InChIKey: CDBYEQYEPGILFF-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(Cl)C=C1)N2C3=C(C=C(OC)C=C3)C(CC(OC4=CC(CO[N+]([O-])=O)=CC=C4)=O)=C2C
Biological Activity: NCX-530 is an Indomethacin (HY-14397) molecule chemically conjugated with a NO moiety. NCX-530 can release NO. NCX-530 can inhibit cancer cells proliferation and induce apoptosis. NCX-530 can be used for the researches of cancer and inflammation[1][2].
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NCX-530 | NCX-530 is an Indomethacin (HY-14397) molecule chemically conjugated with a NO moiety. NCX-530 can release NO. NCX-530 can inhibit cancer cells proliferation and induce apoptosis. NCX-530 can be used for the researches of cancer and inflammation. | |||||||||||||||||||||
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References
- [1]. Ragot T, et al. Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid Res. 2015 Aug 14;8:13. [Content Brief]
- [2]. Takeuchi K, et al. Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals. Dig Dis Sci. 2001 Aug;46(8):1805-18. [Content Brief]
Keywords
