NCX-530
NCX-530 is an Indomethacin (HY-14397) molecule chemically conjugated with a NO moiety. NCX-530 can release NO. NCX-530 can inhibit cancer cells proliferation and induce apoptosis. NCX-530 can be used for the researches of cancer and inflammation.
For research use only. We do not sell to patients.
- CAS No.: 204268-63-3
- Formula: C26H21ClN2O7
- Molecular Weight:508.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NCX-530 (100-200 μM) inhibits proliferation in TT cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 204268-63-3
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Molecular Weight 508.91
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Formula C26H21ClN2O7
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SMILES
O=C(C1=CC=C(Cl)C=C1)N2C3=C(C=C(OC)C=C3)C(CC(OC4=CC(CO[N+]([O-])=O)=CC=C4)=O)=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ragot T, et al. Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid Res. 2015 Aug 14;8:13. [Content Brief]
[2]. Takeuchi K, et al. Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals. Dig Dis Sci. 2001 Aug;46(8):1805-18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NCX-530 Related Classifications
HY-105455 Related Classifications
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