2363082-87-3
2363082-87-3
Chemical Structure
ACT-1014-6470
- CAS 番号: 2363082-87-3
- Formula:C28H29F6N5O
- Molecular Weight:565.55
InChIKey: YPWBQOVYMUEXJT-UHFFFAOYSA-N
SMILES: O=C1N(CC2=CC=CC=C2C(F)(F)F)C3=NN(CC(F)(F)C)C=C3CN1C4CCN(C5=C(C)C=CC=C5F)CC4
Biological Activity: ACT-1014-6470 is an orally active, potent, reversible, and selective C5aR1 antagonist. ACT-1014-6470 demonstrates potent inhibition of C5aR1 activation. ACT-1014-6470 can be used in the research of inflammatory diseases[1][2].
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ACT-1014-6470 | ACT-1014-6470 is an orally active, potent, reversible, and selective C5aR1 antagonist. ACT-1014-6470 demonstrates potent inhibition of C5aR1 activation. ACT-1014-6470 can be used in the research of inflammatory diseases. | |||||||||||||||||||||
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References
- [1]. Sylvie FROIDEVAUX, et al. 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases. WO2019137927A1. WIPO (PCT). 2019-01-09.
- [2]. Ort M, et al. First-in-human study with ACT-1014-6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients. Basic Clin Pharmacol Toxicol. 2022 Aug;131(2):114-128. [Content Brief]
