2477726-83-1
2477726-83-1
Chemical Structure
EGFR-IN-56
- CAS No.: 2477726-83-1
- Formula:C23H22N4O3S
- Molecular Weight:434.51
IUPAC Name: N-(3-((2-((4-methoxyphenyl)amino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
InChIKey: MXQIWUCOUMEFAW-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC=CC(OC2=C(CSCC3)C3=NC(NC4=CC=C(OC)C=C4)=N2)=C1)=O
Biological Activity: EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].
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EGFR-IN-56 | EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis. | |||||||||||||||||||||
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References
Keywords
