1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Apoptosis
  2. EGFR
    Apoptosis
  3. EGFR-IN-56

EGFR-IN-56 

Cat. No.: HY-146136
Handling Instructions

EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis.

For research use only. We do not sell to patients.

EGFR-IN-56 Chemical Structure

EGFR-IN-56 Chemical Structure

CAS No. : 2477726-83-1

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Description

EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].

IC50 & Target

EGFRL858R/T790M

132.1 nM (IC50)

EGFRT790M

541.7 nM (IC50)

Molecular Weight

434.51

Formula

C23H22N4O3S

CAS No.
SMILES

C=CC(NC1=CC=CC(OC2=C(CSCC3)C3=NC(NC4=CC=C(OC)C=C4)=N2)=C1)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EGFR-IN-56
Cat. No.:
HY-146136
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