2704623-69-6
Chemical Structure
NOD1/2 antagonist-1
- CAS No.: 2704623-69-6
- Formula:C32H28ClF5N4O4
- Molecular Weight:663.03
IUPAC Name: 6-(3-chlorophenyl)-3-(2-(3,3-difluoropiperidin-1-yl)-2-oxoethyl)-4-oxo-N-(3-(4-(trifluoromethyl)phenoxy)propyl)-3,4-dihydroquinazoline-7-carboxamide
InChIKey: PWUKTCOWFUUYOZ-UHFFFAOYSA-N
SMILES: O=C(C1=C(C=C2C(N(C=NC2=C1)CC(N3CCCC(F)(C3)F)=O)=O)C4=CC(Cl)=CC=C4)NCCCOC5=CC=C(C=C5)C(F)(F)F
Biological Activity: NOD1/2 antagonist-1 (compound 36b) is a potent NOD1/2 (nucleotide-binding oligomerization domain-like receptor 1/2) dual antagonist, with IC50 values of 1.13 (NOD1) and 0.77 μM (NOD2), respectively. NOD1/2 antagonist-1 has a acceptable T1/2 (67.6 min). NOD1/2 antagonist-1 (compound 36b) can improve the antitumor efficacy of Paclitaxel (PTX)[1].
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NOD1/2 antagonist-1 | NOD1/2 antagonist-1 (compound 36b) is a potent NOD1/2 (nucleotide-binding oligomerization domain-like receptor 1/2) dual antagonist, with IC50 values of 1.13 (NOD1) and 0.77 μM (NOD2), respectively. NOD1/2 antagonist-1 has a acceptable T1/2 (67.6 min). NOD1/2 antagonist-1 (compound 36b) can improve the antitumor efficacy of Paclitaxel (PTX). | |||||||||||||||||||||
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