2953276-07-6
Chemical Structure
RM-041
- CAS No.: 2953276-07-6
- Formula:C54H72F3N9O8
- Molecular Weight:1032.20
InChIKey: RHCPOMMTRYMUIC-ITKRRCNMSA-N
SMILES: O=C(N1COC2(C1C)CCN(CC2)C(N([C@H](C(C)C)C(N[C@H]3C(N4N[C@@H](CCC4)C(OCC(C)(CC5=[C@@]([C@@]6=C([C@H](C)OC)N=CC=C6)N(CC(F)(F)F)C7=CC=C(C8=CCCN(C3)C8)C=C57)C)=O)=O)=O)C)=O)C=C
Biological Activity: RM-041 is a selective, orally active KRASG13C (ON) inhibitor that forms a covalent complex with KRASG13C (ON) and Cyclophilin A. RM-041 blocks the binding of RAS effector proteins via steric hindrance, and then covalently binds to Cys-13 to form an irreversible inhibitory complex, thereby inhibiting the proliferation of KRASG13C mutant cancer cells. RM-041 induces regression of KRASG13C tumors in cellular and xenograft tumor models. RM-041 exerts a synergistic effect when combined with upstream node inhibitors (such as SHP2 inhibitors). RM-041 can be used for the research of non-small cell lung cancer[1].
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RM-041 | RM-041 is a selective, orally active KRASG13C (ON) inhibitor that forms a covalent complex with KRASG13C (ON) and Cyclophilin A. RM-041 blocks the binding of RAS effector proteins via steric hindrance, and then covalently binds to Cys-13 to form an irreversible inhibitory complex, thereby inhibiting the proliferation of KRASG13C mutant cancer cells. RM-041 induces regression of KRASG13C tumors in cellular and xenograft tumor models. RM-041 exerts a synergistic effect when combined with upstream node inhibitors (such as SHP2 inhibitors). RM-041 can be used for the research of non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
