29734-68-7
Chemical Structure
Dihydro-β-erythroidine hydrobromide
Synonym(s): DHβE hydrobromide
- CAS No.: 29734-68-7
- Formula:C16H22BrNO3
- Molecular Weight:356.25
IUPAC Name: (2S,13bS)-2-methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-pyrano[4',3':3,4]pyrido[2,1-i]indol-12-one hydrobromide
InChIKey: GFIGWAJEIMHJJB-LINSIKMZSA-N
SMILES: CO[C@@H]1C[C@]23C(CC4=O)=C(CO4)CCN2CCC3=CC1.Br
Biological Activity: Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dihydro-β-erythroidine hydrobromide | 99.96% | Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities. | ||||||||||||||||||||
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- [1]. Harvey SC, et al. Multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. J Neurochem. 1996 Nov;67(5):1953-9. [Content Brief]
- [2]. Tabbara RI, et al. Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex. Neuropharmacology. 2019 Apr;148:68-76. [Content Brief]
- [3]. Clementson S, et al. Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine. J Am Chem Soc. 2019 Jun 5;141(22):8783-8786. [Content Brief]
Keywords
