3011748-20-9
Chemical Structure
Pro-PTX
- CAS No.: 3011748-20-9
- Formula:C56H63N3O17
- Molecular Weight:1050.11
IUPAC Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((R)-2-((S)-benzamido(phenyl)methyl)-5,8-dimethyl-4,9-dioxo-3,10-dioxa-5,8-diazatridec-12-ynoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate
InChIKey: YUOKZFRQVPPLJZ-SIWBBEJASA-N
SMILES: CC1=C([C@@H](OC(C)=O)C([C@@]2(C)[C@]([C@@](CO3)(OC(C)=O)[C@@]3([H])C[C@@H]2O)([H])[C@@H]4OC(C5=CC=CC=C5)=O)=O)C(C)(C)[C@@]4(O)C[C@@H]1OC([C@H](OC(N(CCN(C(OCC#C)=O)C)C)=O)[C@@H](NC(C6=CC=CC=C6)=O)C7=CC=CC=C7)=O
Biological Activity: Pro-PTX is a Pd-sensitive Paclitaxel (HY-B0015) prodrug with anticancer activity. Pro-PTX triggers intramolecular cyclization via Pd-catalyzed depropargylation to release active Paclitaxel (HY-B0015) and a non-toxic byproduct. Pro-PTX exhibits low cytotoxicity and antiproliferative activity in cancer cells and non-cancerous human cerebrovascular pericytes. Pro-PTX is applicable for research related to non-small cell lung cancer, glioblastoma and lung cancer[1][2].
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Pro-PTX | Pro-PTX is a Pd-sensitive Paclitaxel (HY-B0015) prodrug with anticancer activity. Pro-PTX triggers intramolecular cyclization via Pd-catalyzed depropargylation to release active Paclitaxel (HY-B0015) and a non-toxic byproduct. Pro-PTX exhibits low cytotoxicity and antiproliferative activity in cancer cells and non-cancerous human cerebrovascular pericytes. Pro-PTX is applicable for research related to non-small cell lung cancer, glioblastoma and lung cancer. | |||||||||||||||||||||
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References
- [1]. Pérez-López AM, et al. Bioorthogonal Uncaging of Cytotoxic Paclitaxel through Pd Nanosheet-Hydrogel Frameworks. J Med Chem. 2020;63(17):9650-9659. [Content Brief]
- [2]. Sancho-Albero M, et al. Extracellular Vesicles-Mediated Bio-Orthogonal Catalysis in Growing Tumors. Cells. 2024;13(8):691. Published 2024 Apr 16. [Content Brief]
