301334-89-4
Chemical Structure
2-Chloro-ATP sodium
- CAS No.: 301334-89-4
- Formula:C10H11ClN5Na4O13P3
- Molecular Weight:629.55
IUPAC Name: sodium ((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate
InChIKey: JGKMWMQAWOVZHJ-ZVQJTLEUSA-J
SMILES: O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])N2C3=NC(Cl)=NC(N)=C3N=C2
Biological Activity:
2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.
The product specifications provided below refer solely to the active content of 2-Chloro-ATP sodium.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
2-Chloro-ATP sodium | 98.41% | 2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG. The product specifications provided below refer solely to the active content of 2-Chloro-ATP sodium. |
||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.90
HY-131776A2-Chloro-ADP sodium solution (10 mM) -
Similarity Score 0.86
HY-1013702-Methylthio-ATP tetrasodium -
Similarity Score 0.81
HY-134290A8-Chloro-ATP tetrasodium -
Similarity Score 0.79
HY-134313A8-NH2-ATP tetrasodium -
Similarity Score 0.78
HY-1086482-MeS-ADP trisodium -
Similarity Score 0.78
HY-137658APurine riboside-5'-O-triphosphate sodium -
Similarity Score 0.77
HY-1366478-Bromoadenosine 5'-triphosphate tetrasodium -
Similarity Score 0.77
HY-134361ATP-γ-S tetrasodium -
Similarity Score 0.76
HY-1373252-Chloro-ATP -
Explore the MedChemAI to find more analogs
