303215-67-0
Chemical Structure
MitoBloCK-6
- CAS No.: 303215-67-0
- Formula:C19H14Cl2N2O
- Molecular Weight:357.23
IUPAC Name: (E)-2,4-dichloro-6-(((4-(phenylamino)phenyl)imino)methyl)phenol
InChIKey: DBYOPSAQYAKIQV-WSDLNYQXSA-N
SMILES: OC1=C(/C=N/C2=CC=C(NC3=CC=CC=C3)C=C2)C=C(Cl)C=C1Cl
Biological Activity: MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce Apoptosis via cytochrome c release. MitoBloCK-6 inhibits growth of developing zebrafish motor neurons. MitoBloCK-6 has anticancer activity against liver cancer and leukemia[1][2][3][4][5][6].
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MitoBloCK-6 | 98.0% | MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce Apoptosis via cytochrome c release. MitoBloCK-6 inhibits growth of developing zebrafish motor neurons. MitoBloCK-6 has anticancer activity against liver cancer and leukemia. | ||||||||||||||||||||
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- [1]. Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92. [Content Brief]
- [2]. Kabiri Y, et al. Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation. Front Cell Dev Biol. 2021 Sep 20;9:725474. [Content Brief]
- [3]. Jeyaraju D V, et al. Inhibition of the mitochondrial protein import machinery is selectively cytotoxic to acute myeloid leukemia (AML) cells and stem cells. Blood, 2016, 128(22): 1572.
- [4]. Singh RP, et al. Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal. Cell Stem Cell. 2020 Jun 4;26(6):926-937.e10. [Content Brief]
- [5]. Johnson M E. One Fish, Two Fish, Small Fish, Huge Fish: Utilizing Zebrafish as a Model for Studying Mitochondrial Function. UCLA, 2012.
- [6]. Jeyaraju D V, et al. Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells. 2017.
Keywords
