2. Apoptosis
  3. Apoptosis
  4. MitoBloCK-6

MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs.

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MitoBloCK-6 Chemical Structure

MitoBloCK-6 Chemical Structure

CAS No. : 303215-67-0

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Based on 1 publication(s) in Google Scholar

MitoBloCK-6 Related Antibodies

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Description

MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs[1].

IC50 & Target

IC50: 900 nM (Erv1) 700 nM (ALR) 1.4 μM (Erv2)[1]
Molecular Weight

357.23

Formula

C19H14Cl2N2O
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

OC1=C(/C=N/C2=CC=C(NC3=CC=CC=C3)C=C2)C=C(Cl)C=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (139.97 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7993 mL 13.9966 mL 27.9932 mL
5 mM 0.5599 mL 2.7993 mL 5.5986 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.07%

COA (246 KB) HNMR (249 KB) LCMS (271 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7993 mL 13.9966 mL 27.9932 mL 69.9829 mL
5 mM 0.5599 mL 2.7993 mL 5.5986 mL 13.9966 mL
10 mM 0.2799 mL 1.3997 mL 2.7993 mL 6.9983 mL
15 mM 0.1866 mL 0.9331 mL 1.8662 mL 4.6655 mL
20 mM 0.1400 mL 0.6998 mL 1.3997 mL 3.4991 mL
25 mM 0.1120 mL 0.5599 mL 1.1197 mL 2.7993 mL
30 mM 0.0933 mL 0.4666 mL 0.9331 mL 2.3328 mL
40 mM 0.0700 mL 0.3499 mL 0.6998 mL 1.7496 mL
50 mM 0.0560 mL 0.2799 mL 0.5599 mL 1.3997 mL
60 mM 0.0467 mL 0.2333 mL 0.4666 mL 1.1664 mL
80 mM 0.0350 mL 0.1750 mL 0.3499 mL 0.8748 mL
100 mM 0.0280 mL 0.1400 mL 0.2799 mL 0.6998 mL
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MitoBloCK-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MitoBloCK-6303215-67-0MitoBloCK6MitoBloCK 6ApoptosisErv1ALRErv2apoptosisInhibitorinhibitorinhibit

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