3034516-68-9
3034516-68-9
Chemical Structure
PARL-IN-1
- CAS No.: 3034516-68-9
- Formula:C39H56N6O7
- Molecular Weight:720.90
IUPAC Name: ethyl (R)-5-methyl-4-oxo-5-(trifluoromethyl)-4,5-dihydrofuran-2-carboxylate
InChIKey: GRZBUTPJWIBTNF-USYGSZCGSA-N
SMILES: C[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(C(NCCCCC1=CC=CC=C1)=O)=O)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O
Biological Activity: PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy[1].
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PARL-IN-1 | 96.57% | PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy. | ||||||||||||||||||||
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References
Keywords
