PARL-IN-1
Based on 1 Customer Validation
PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy.
For research use only. We do not sell to patients.
- Purity: 96.57%
- CAS No.: 3034516-68-9
- Formula: C39H56N6O7
- Molecular Weight:720.90
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 28 nM (PARL)[1]
PARL-IN-1 (compound 5; 5 nM-20 μM) impedes mitochondrial stress-induced cleavage of PGAM by PARL in cells and inhibits the cleavage of overexpressed human PGAM5 in HEK293T cells in a dose-dependent manner[1].
PARL-IN-1 (0.1-30 μM; 8 h; HEK293T cells) stabilizes PINK1 and triggers its alternative cleavage and trafficking in living cells[1].
PARL-IN-1 (5 μM; 22 h; HEK293 T-REx cells) blocks the respiratory chain leading to aberrant reactive oxygen species (ROS) production, activates the PINK1/Parkin pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells
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Concentration:0.1, 0.3, 1, 3, 10, and 30 μM
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Incubation Time:8 hours
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Result:Inhibitd the PARL-cleavage of overexpressed PINK1 in a dose-dependent manner.
Chemical Information
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CAS No. 3034516-68-9
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Appearance Solid
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Molecular Weight 720.90
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Formula C39H56N6O7
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Color White to off-white
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SMILES
C[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(C(NCCCCC1=CC=CC=C1)=O)=O)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (13.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3872 mL | 6.9358 mL | 13.8715 mL | 34.6789 mL |
| 5 mM | 0.2774 mL | 1.3872 mL | 2.7743 mL | 6.9358 mL | |
| 10 mM | 0.1387 mL | 0.6936 mL | 1.3872 mL | 3.4679 mL |
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