314054-36-9
Chemical Structure
HIOC
- CAS No.: 314054-36-9
- Formula:C16H19N3O3
- Molecular Weight:301.34
IUPAC Name: N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide
InChIKey: ZIMKJLALTRLXJO-UHFFFAOYSA-N
SMILES: O=C(C1C(NCCC1)=O)NCCC2=CNC3=C2C=C(O)C=C3
Biological Activity: HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HIOC | 99.94% | HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration. | ||||||||||||||||||||
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- [1]. Tang J, et al. Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model. Neurobiol Dis. 2015 Jun;78:126-33. [Content Brief]
- [2]. Noah A.Setterholm, et al.Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC). Tetrahedron Letters. 3 June 2015;56(23):3413-3415.
- [3]. Ying Li, et al. Effect of systemic treatment with N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3- carboxamide (HIOC) or tauroursodeoxycholic Acid (TUDCA) on retinal ganglion cell death following optic nerve crush. bioRxiv. 2019 August 14.
Keywords
