Cat. No.: HY-101446

HIOC

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration.

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 314054-36-9
Formula: C₁₆H₁₉N₃O₃
Molecular Weight:301.34

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

HIOC Chemical Structure

CAS No.: 314054-36-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

TrkB

ERK

All Trk Receptor Isoforms :

All ERK Isoforms :

In Vivo

HIOC (C57BL/6 mice, 50 mg/kg, IP, three times per week, for two weeks) increased survival of RGCs (retinal ganglion cells) after ONC (optic nerve crush)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 314054-36-9
Appearance Solid
Molecular Weight 301.34
Formula C₁₆H₁₉N₃O₃
Color White to off-white
SMILES

O=C(C1C(NCCC1)=O)NCCC2=CNC3=C2C=C(O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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J Biol Chem

Stress-induced glucocorticoid signaling impairs enteric neurotrophin BDNF-TrkB pathway and drives gastrointestinal dysmotility. [Abstract]

2026 Apr 27;302(7):113095. PMID: 42055341

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (331.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3185 mL

16.5926 mL

33.1851 mL

5 mM

0.6637 mL

3.3185 mL

6.6370 mL

10 mM

0.3319 mL

1.6593 mL

3.3185 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang J, et al. Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model. Neurobiol Dis. 2015 Jun;78:126-33. [Content Brief]

[2]. Noah A.Setterholm, et al.Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC). Tetrahedron Letters. 3 June 2015;56(23):3413-3415.

[3]. Ying Li, et al. Effect of systemic treatment with N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3- carboxamide (HIOC) or tauroursodeoxycholic Acid (TUDCA) on retinal ganglion cell death following optic nerve crush. bioRxiv. 2019 August 14.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3185 mL	16.5926 mL	33.1851 mL	82.9628 mL
	5 mM	0.6637 mL	3.3185 mL	6.6370 mL	16.5926 mL
	10 mM	0.3319 mL	1.6593 mL	3.3185 mL	8.2963 mL
	15 mM	0.2212 mL	1.1062 mL	2.2123 mL	5.5309 mL
	20 mM	0.1659 mL	0.8296 mL	1.6593 mL	4.1481 mL
	25 mM	0.1327 mL	0.6637 mL	1.3274 mL	3.3185 mL
	30 mM	0.1106 mL	0.5531 mL	1.1062 mL	2.7654 mL
	40 mM	0.0830 mL	0.4148 mL	0.8296 mL	2.0741 mL
	50 mM	0.0664 mL	0.3319 mL	0.6637 mL	1.6593 mL
	60 mM	0.0553 mL	0.2765 mL	0.5531 mL	1.3827 mL
	80 mM	0.0415 mL	0.2074 mL	0.4148 mL	1.0370 mL
	100 mM	0.0332 mL	0.1659 mL	0.3319 mL	0.8296 mL

Keywords

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HIOC

Apoptosis Compound Library

Immunology/Inflammation Compound Library

MAPK Compound Library

Neuronal Signaling Compound Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

CNS-Penetrant Compound Library

Anti-Aging Compound Library

Oxygen Sensing Compound Library

Glutamine Metabolism Compound Library

Neuroprotective Compound Library

Angiogenesis-Related Compound Library

Antidepressant Compound Library

Osteogenesis Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) HIOC

All Trk Receptor Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

HIOC Related Classifications

Cat. No.: HY-101446