3222-88-6
Chemical Structure
R-6890
- CAS No.: 3222-88-6
- Formula:C21H24ClN3O
- Molecular Weight:369.89
InChIKey: KFEYPBZJPJJRFX-UHFFFAOYSA-N
SMILES: O=C1NCN(C12CCN(C(C)C3=CC=C(C=C3)Cl)CC2)C4=CC=CC=C4
Biological Activity: R-6890 is a Brorphine-related opioid receptor antagonist that exhibits differential binding activities toward rat opioid receptors (IC50=4.6 nM (0.05 M Tris; pH 7.4) and 170 nM (0.05 M Tris+0.1 M NaCl)). R-6890 displaces bound labeled opioids from receptors, and its binding affinity is affected by environmental factors, decreasing in the presence of NaCl. R-6890 crosses the blood-brain barrier (BBB) and exerts analgesic effects in the warm water-induced tail-flick reflex model of male Wistar rats[1][2].
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R-6890 | 99.59% | R-6890 is a Brorphine-related opioid receptor antagonist that exhibits differential binding activities toward rat opioid receptors (IC50=4.6 nM (0.05 M Tris; pH 7.4) and 170 nM (0.05 M Tris+0.1 M NaCl)). R-6890 displaces bound labeled opioids from receptors, and its binding affinity is affected by environmental factors, decreasing in the presence of NaCl. R-6890 crosses the blood-brain barrier (BBB) and exerts analgesic effects in the warm water-induced tail-flick reflex model of male Wistar rats. | ||||||||||||||||||||
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- [1]. Stahl KD, et al. Receptor affinity and pharmacological potency of a series of narcotic analgesic, anti-diarrheal and neuroleptic drugs. Eur J Pharmacol. 1977;46(3):199-205. [Content Brief]
- [2]. Marchei E, et al. Brorphine and Its Analogues: Pharmacology, Toxicology, and Biomonitoring. Ther Drug Monit. Published online February 2, 2026. [Content Brief]
Keywords
