33984-50-8
Chemical Structure
MBD
Synonym(s): 7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole
- CAS No.: 33984-50-8
- Formula:C14H12N4O4
- Molecular Weight:300.27
IUPAC Name: N-(4-methoxybenzyl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine
InChIKey: IENONFJSMWUIQQ-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(NCC2=CC=C(OC)C=C2)C3=NON=C31)[O-]
Biological Activity: MBD (7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole) is a hydrophobic fluorescent probe that is used to detect conformational changes of the complement subcomponent C1r during its autoactivation process. MBD acts by selectively binding to exposed hydrophobic regions on the C1r macromolecule. The detection wavelength of MBD in the free unbound state is Ex/Em = 490/560 nm, whereas the maximum emission wavelength of MBD upon binding to C1r exhibits a blue shift of approximately 20 nm relative to 560 nm[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MBD | 99.60% | MBD (7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole) is a hydrophobic fluorescent probe that is used to detect conformational changes of the complement subcomponent C1r during its autoactivation process. MBD acts by selectively binding to exposed hydrophobic regions on the C1r macromolecule. The detection wavelength of MBD in the free unbound state is Ex/Em = 490/560 nm, whereas the maximum emission wavelength of MBD upon binding to C1r exhibits a blue shift of approximately 20 nm relative to 560 nm. | ||||||||||||||||||||
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References
- [1]. Kenner RA, et al. A new fluorescent probe for protein and nucleoprotein conformation. Binding of 7-(p-methoxybenzylamino)-4-nitrobenzoxadiazole to bovine trypsinogen and bacterial ribosomes. Biochemistry. 1971 Nov 23;10(24):4433-40. [Content Brief]
- [2]. Kasahara Y, et al. Formation of a conformationally changed C1r, a subcomponent of the first component of human complement, as an intermediate of its autoactivation reaction. FEBS Lett. 1982 May 3;141(1):128-31. [Content Brief]
