38482-81-4
Chemical Structure
Genistein 7-β-D-Glucuronide
Synonym(s): Genistein 7-O-glucuronide
- CAS No.: 38482-81-4
- Formula:C21H18O11
- Molecular Weight:446.36
IUPAC Name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
InChIKey: JIVINIISUDEORF-ZFORQUDYSA-N
SMILES: O=C1C(C(OC=C1C(C=C2)=CC=C2O)=CC(O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)C(O)=O)=C4)=C4O
Biological Activity: Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism[1][2][3].
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Genistein 7-β-D-Glucuronide | 98.76% | Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism. | ||||||||||||||||||||
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References
- [1]. Giménez-Bastida JA, et al. (R,S)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway. Food Funct. 2024;15(14):7387-7399. Published 2024 Jul 15. [Content Brief]
- [2]. Bursztyka J, et al. Comparison of genistein metabolism in rats and humans using liver microsomes and hepatocytes. Food Chem Toxicol. 2008;46(3):939-948. [Content Brief]
- [3]. Bolling BW, et al. The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes. J Nutr Biochem. 2010;21(6):498-503. [Content Brief]
