517-46-4
Chemical Structure
Strictinin
- CAS No.: 517-46-4
- Formula:C27H22O18
- Molecular Weight:634.45
IUPAC Name: (11aR,13S,14R,15R,15aS)-2,3,4,5,6,7,14,15-octahydroxy-9,17-dioxo-9,11,11a,13,14,15,15a,17-octahydrodibenzo[g,i]pyrano[3,2-b][1,5]dioxacycloundecin-13-yl 3,4,5-trihydroxybenzoate
InChIKey: FYIJLTSMNXUNLT-CXQFPWCTSA-N
SMILES: O[C@H]1[C@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)O[C@H](COC3=O)[C@@H](OC(C4=CC(O)=C(O)C(O)=C4C5=C(O)C(O)=C(O)C=C53)=O)[C@@H]1O
Biological Activity: Strictinin is an orally active phenolic compound. Strictinin reduces xanthine oxidase activity, uric acid production, and the activation of ERK1/2, JNK, NF-κB, and NLRP3 inflammasome components in hepatocytes treated with Xanthine (HY-W017389). Strictinin decreases elevated serum uric acid levels and enhanced xanthine oxidase activity in mice treated with potassium oxonate. Strictinin acts as a ROR1 inhibitor and exhibits anticancer activity against highly aggressive non-androgen-dependent prostate cancer. Strictinin induces cancer cell apoptosis (apoptosis), arrests cell cycle, and inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition. Strictinin modulates gut microbiota, inhibits bacterial growth and biofilm formation, accelerates small intestinal transit, and blocks viral entry and replication. Strictinin can be used in research related to hyperuricemia, androgen receptor-negative non-androgen-dependent prostate cancer, triple-negative breast cancer, bacterial infections, constipation, coronavirus infections, dental caries, and infections caused by influenza A, influenza B, and human parainfluenza virus type 1[1][2][3][4][5][6][7].
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Strictinin | 97.15% | Strictinin is an orally active phenolic compound. Strictinin reduces xanthine oxidase activity, uric acid production, and the activation of ERK1/2, JNK, NF-κB, and NLRP3 inflammasome components in hepatocytes treated with Xanthine (HY-W017389). Strictinin decreases elevated serum uric acid levels and enhanced xanthine oxidase activity in mice treated with potassium oxonate. Strictinin acts as a ROR1 inhibitor and exhibits anticancer activity against highly aggressive non-androgen-dependent prostate cancer. Strictinin induces cancer cell apoptosis (apoptosis), arrests cell cycle, and inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition. Strictinin modulates gut microbiota, inhibits bacterial growth and biofilm formation, accelerates small intestinal transit, and blocks viral entry and replication. Strictinin can be used in research related to hyperuricemia, androgen receptor-negative non-androgen-dependent prostate cancer, triple-negative breast cancer, bacterial infections, constipation, coronavirus infections, dental caries, and infections caused by influenza A, influenza B, and human parainfluenza virus type 1. | ||||||||||||||||||||
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- [1]. Huang KC, et al. Alleviation of Hyperuricemia by Strictinin in AML12 Mouse Hepatocytes Treated with Xanthine and in Mice Treated with Potassium Oxonate. Biology (Basel). 2023;12(2):329. Published 2023 Feb 17. [Content Brief]
- [2]. Sivaganesh V, et al. Receptor tyrosine kinase-like orphan receptor 1 inhibitor strictinin exhibits anti-cancer properties against highly aggressive androgen-independent prostate cancer. Explor Target Antitumor Ther. 2023;4(6):1188-1209. [Content Brief]
- [3]. Fultang N, et al. Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity. PLoS One. 2019;14(5):e0217789. Published 2019 May 31. [Content Brief]
- [4]. Hsieh SK, et al. Antibacterial and laxative activities of strictinin isolated from Pu'er tea (Camellia sinensis). J Food Drug Anal. 2016;24(4):722-729. [Content Brief]
- [5]. Tu EC, et al. Strictinin, a Major Ingredient in Yunnan Kucha Tea Possessing Inhibitory Activity on the Infection of Mouse Hepatitis Virus to Mouse L Cells. Molecules. 2023;28(3):1080. Published 2023 Jan 21. [Content Brief]
- [6]. Liao MH, et al. Pu'er tea rich in strictinin and catechins prevents biofilm formation of two cariogenic bacteria, Streptococcus mutans and Streptococcus sobrinus. J Dent Sci. 2021 Oct;16(4):1331-1334. [Content Brief]
- [7]. Saha RK, et al. Antiviral effect of strictinin on influenza virus replication. Antiviral Res. 2010;88(1):10-18. [Content Brief]
Keywords
