52962-95-5
Chemical Structure
Redoxal
- CAS No.: 52962-95-5
- Formula:C28H24N2O6
- Molecular Weight:484.50
InChIKey: IQZIRNIZQHVBMB-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=CC=C(C3=CC(OC)=C(NC4=C(C(O)=O)C=CC=C4)C=C3)C=C2OC)C=CC=C1)O
Biological Activity: Redoxal is a dihydroorotate dehydrogenase (DHODH) inhibitor and anti-HIV-1 agent. Redoxal induces intracellular pyrimidine depletion by inhibiting the de novo pyrimidine biosynthesis pathway, enhances the protein stability of APOBEC3G (A3G), upregulates the abundance of A3G protein in cells and progeny viral particles, thereby strengthening the host endogenous antiviral restriction mediated by A3G. Redoxal selectively targets DHOdehase at the mitochondrial level, with an IC50 of 430 nM for inhibiting DHO oxidation in human mitochondria and an IC50 of 910 nM in rat mitochondria. Redoxal can be used in studies related to HIV-1 infection[1][2].
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Redoxal | Redoxal is a dihydroorotate dehydrogenase (DHODH) inhibitor and anti-HIV-1 agent. Redoxal induces intracellular pyrimidine depletion by inhibiting the de novo pyrimidine biosynthesis pathway, enhances the protein stability of APOBEC3G (A3G), upregulates the abundance of A3G protein in cells and progeny viral particles, thereby strengthening the host endogenous antiviral restriction mediated by A3G. Redoxal selectively targets DHOdehase at the mitochondrial level, with an IC50 of 430 nM for inhibiting DHO oxidation in human mitochondria and an IC50 of 910 nM in rat mitochondria. Redoxal can be used in studies related to HIV-1 infection. | |||||||||||||||||||||
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- [1]. Pery E, et al. Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1. Virology. 2015;484:276-287. [Content Brief]
- [2]. Knecht W, et al. Redoxal as a new lead structure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism. FEBS Lett. 2000;467(1):27-30. [Content Brief]
Keywords
