5588-10-3
Chemical Structure
Methoxyphenamine hydrochloride
Synonym(s): NSC-65644
- CAS No.: 5588-10-3
- Formula:C11H18ClNO
- Molecular Weight:215.72
IUPAC Name: 1-(2-methoxyphenyl)-N-methylpropan-2-amine hydrochloride
InChIKey: FGSJNNQVSUVTPW-UHFFFAOYSA-N
SMILES: COC1=CC=CC=C1CC(C)NC.[H]Cl
Biological Activity: Methoxyphenamine hydrochloride (NSC-65644) is a bronchodilator. Methoxyphenamine hydrochloride exhibits α- and β-adrenergic receptor agonist effects. Methoxyphenamine hydrochloride reduces basal nasal resistance and inhibits Histamine (HY-B1204)-induced nasal congestion. Methoxyphenamine hydrochloride undergoes metabolism mediated by CYP2D6. Methoxyphenamine hydrochloride can be used in research related to nasal congestion and bronchial asthma[1][2][3][4].
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Methoxyphenamine hydrochloride | 98.0% | Methoxyphenamine hydrochloride (NSC-65644) is a bronchodilator. Methoxyphenamine hydrochloride exhibits α- and β-adrenergic receptor agonist effects. Methoxyphenamine hydrochloride reduces basal nasal resistance and inhibits Histamine (HY-B1204)-induced nasal congestion. Methoxyphenamine hydrochloride undergoes metabolism mediated by CYP2D6. Methoxyphenamine hydrochloride can be used in research related to nasal congestion and bronchial asthma. | ||||||||||||||||||||
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- [1]. Lau WA, et al. Methoxyphenamine inhibits basal and histamine-induced nasal congestion in anaesthetized rats. British journal of pharmacology. 1990 Oct;101(2):394-8. [Content Brief]
- [2]. Geertsen S, et al. Metabolism of methoxyphenamine and 2-methoxyamphetamine in P4502D6-transfected cells and cell preparations. Xenobiotica; the fate of foreign compounds in biological systems. 1995 Sep;25(9):895-906. [Content Brief]
- [3]. Thevis M, et al. Doping control analysis of methoxyphenamine using liquid chromatography-tandem mass spectrometry. European journal of mass spectrometry (Chichester, England). 2008;14(3):145-52. [Content Brief]
- [4]. Phillis JW, et al. The effect of alpha-, beta adrenergic receptor agonists and antagonists on the efflux of 22Na and uptake of 42K by rat brain cortical slices. Brain Res. 1982 Mar 18;236(1):133-42. [Content Brief]
Keywords
