6659-45-6
Chemical Structure
Dihydrorotenone
- CAS No.: 6659-45-6
- Formula:C23H24O6
- Molecular Weight:396.43
IUPAC Name: (2R,6aS,12aS)-2-isopropyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one
InChIKey: DTFARBHXORYQBF-HBGVWJBISA-N
SMILES: O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C(O[C@@H](C(C)C)C5)=CC=C14
Biological Activity: Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD50 of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dihydrorotenone | 99.66% | Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD50 of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies. | ||||||||||||||||||||
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- [1]. Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8(7):e69911. [Content Brief]
- [2]. Caboni P, et al. Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease. Chem Res Toxicol. 2004 Nov;17(11):1540-8. [Content Brief]
- [3]. AMBROSE AM, et al. Toxicological and pharmacological studies on dihydrorotenone. J Am Pharm Assoc Am Pharm Assoc. 1953 Jun;42(6):364-6. [Content Brief]
- [4]. Kim K J, et al. Inhibitory Effects of 1', 2'-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo. 해부· 생물인류학, 2011, 24(3): 165-174.
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