952739-54-7
952739-54-7
Chemical Structure
(R)-IBR2
- CAS 番号: 952739-54-7
- Formula:C24H20N2O2S
- Molecular Weight:400.49
IUPAC Name: (R)-2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline
InChIKey: YCOHEPDJLXZVBZ-XMMPIXPASA-N
SMILES: O=S(N1[C@@H](C2=CNC3=C2C=CC=C3)C4=C(C=CC=C4)C=C1)(CC5=CC=CC=C5)=O
Biological Activity: (R)-IBR2 is the isomer of IBR2 (HY-103710). IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis[1].
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(R)-IBR2 | (R)-IBR2 is the isomer of IBR2 (HY-103710). IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis. | |||||||||||||||||||||
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