97-39-2
97-39-2
Chemical Structure
Ditolylguanidine
Synonym(s): 1,3-Di-o-tolylguanidine; DTG
- CAS No.: 97-39-2
- Formula:C15H17N3
- Molecular Weight:239.32
IUPAC Name: 1,3-di-o-tolylguanidine
InChIKey: OPNUROKCUBTKLF-UHFFFAOYSA-N
SMILES: CC1=C(NC(NC2=CC=CC=C2C)=N)C=CC=C1
Biological Activity: Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ditolylguanidine | 99.75% | Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer. | ||||||||||||||||||||
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Ditolylguanidine (Standard) | 99.20% | Ditolylguanidine (Standard) is the analytical standard of Ditolylguanidine. This product is intended for research and analytical applications. Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer. | ||||||||||||||||||||
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1A-116 (Standard) | ≥98% | 1A-116 (Standard) is the analytical standard of 1A-116 (HY-104064). This product is intended for research and analytical applications. 1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo. | ||||||||||||||||||||
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INH14 | 98.0% | INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity. | ||||||||||||||||||||
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Ameltolide | 98.56% | Ameltolide (LY-201116; ADD 75073) is a novel anticonvulsant agent and can be used for epilepsy research. | ||||||||||||||||||||
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2-Aminobenzanilide | 2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade. | |||||||||||||||||||||
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AK963/40708899 | AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways. | |||||||||||||||||||||
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N,N′-Diphenylthiourea (Standard) | ≥98% | N,N′-Diphenylthiourea (Standard) is the analytical standard of N,N′-Diphenylthiourea. This product is intended for research and analytical applications. N,N′-Diphenylthiourea (Diphenylsulfourea; Thiocarbanilide) is a biological material or organic compound that can be used in life science research. | ||||||||||||||||||||
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1,3-Diphenylurea (Standard) | ≥98% | 1,3-Diphenylurea (Standard) is the analytical standard of 1,3-Diphenylurea. This product is intended for research and analytical applications. 1,3-Diphenylurea is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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1,3-Diphenylguanidine | 99.76% | 1,3-Diphenylguanidine is a widely used accelerator in rubber vulcanization. 1,3-Diphenylguanidine increases ROS activity and decreases SOD and CAT activity. 1,3-Diphenylguanidine accelerates the vulcanization process. 1,3-Diphenylguanidine impairs the reproduction and growth of Moina macrocopa . | ||||||||||||||||||||
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2-Methyl-5-(p-tolyldiazenyl)aniline (Standard) | ≥98% | 2-Methyl-5-(p-tolyldiazenyl)aniline (Standard) is the analytical standard of 2-Methyl-5-(p-tolyldiazenyl)aniline. This product is intended for research and analytical applications. 2-Methyl-5-(p-tolyldiazenyl)aniline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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N,N'-Di-o-tolyl-p-phenylenediamine | 99.86% | N,N'-Di-o-tolyl-p-phenylenediamine is a diphenylamine antioxidant that could be found in wastewater. N,N'-Di-o-tolyl-p-phenylenediamine accumulates in aquatic organisms, exhibits bioaccumulating potential, may have long-term effects on aquatic ecosystems. | ||||||||||||||||||||
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References
- [1]. Shimizu I, et al. Effects of (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. Br J Pharmacol. 2000 Oct;131(3):610-6.
- [2]. John CS, et al. Sigma receptors are expressed in human non-small cell lung carcinoma. Life Sci. 1995;56(26):2385-92. [Content Brief]
- [3]. Moody TW, et al. Sigma ligands inhibit the growth of small cell lung cancer cells. Life Sci. 2000 Apr 7;66(20):1979-86. [Content Brief]
- [4]. Moison D, et al. Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo. Neuropharmacology. 2003 Dec;45(7):945-53. [Content Brief]
