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Art. -Nr.: HY-112823S

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Almonertinib-d₆

(Synonyms: HS-10296-d₆)

Almonertinib-d₆ (HS-10296-d₆) is the deuterium labeled Almonertinib (HY-112823). Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₀H₂₉D₆N₇O₂
Molecular Weight:531.68

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Almonertinib-d₆ Chemical Structure

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Biologische Aktivität
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Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

Alle EGFR Isoform-spezifische Produkte anzeigen :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 1899921-05-1
Molecular Weight 531.68
Formel C₃₀H₂₉D₆N₇O₂
SMILES

COC1=C(NC2=NC(C3=CN(C4=C3C=CC=C4)C5CC5)=CC=N2)C=C(NC(C=C)=O)C(N(CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C)=C1
Synonyms

HS-10296-d₆
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.